Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• are foreign objects, careful evaluation of their toxicological and functional aspects prior to medical application is imperative. In this study, we aimed to determine the effects of gold and polymer-coated silica nanoparticles used in laser tissue soldering on brain endothelial cells and the blood

• metabolic state of cells have to be further characterized before use for medical purposes. Keywords: blood–brain barrier; laser tissue soldering; nanomedicine; nanoparticle uptake; rBCEC4 cells; Introduction Nanotechnology is commonly used in various fields, such as agriculture and pharmaceutical industry

• , and has gained further importance over the past few decades [1]. This technology also offers promising possibilities for medical applications such as tumor diagnostics and therapy, as drug carriers or in biodegradable implants, e.g., in laser tissue soldering (LTS) [2]. LTS provides a promising